CAR: 

From the City: 
Via CTE - Exit 10 - Braddell Road, turn right into Braddell Road, then turn left to Upper Serangoon Road.

From the East: 
Via PIE to CTE - Exit 10 - Braddell Road, turn right into Braddell Road, then turn left to Upper Serangoon Road. Via TPE to CTE - Exit 11 - Ang Mo Kio Ave 1, turn left to Boundary Road, then turn right into Serangoon Central.

From the West: 
Via PIE - Exit 20B - Lornie Road, take flyover to Braddell, then turn left to Upper Serangoon Road.

From the Woodlands: 
Via SLE to CTE - Exit 11 - Ang Mo Kio Ave 1, turn left to Boundary Road, then turn right into Serangoon Central.

BUS: 

22, 43, 45, 53, 53A, 53B, 58, 70, 70M, 81, 82, 100, 101, 103, 105, 107, 107M, 109, 133, 135, 147, 153, 158, 315, 317, 853, NR6

MRT: 

Serangoon MRT station (NE12), North East Line